San Francisco Vacations from $312

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Your San Francisco Vacation

With plenty of highlights as well as hidden gems, this city is best experienced with a San Francisco vacation package. Check out places to stay in Downtown Guayaquil, which is good for views, culture and history. Make your trip to San Francisco even more exciting by including some sightseeing. Malecon 2000, Banco Pichincha Monumental Stadium and Mall del Sol Commercial Center are among the leading attractions worth exploring. A couple of clicks is all it takes to put together a customized San Francisco vacation on Expedia.

The Latest San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Mansión Alcázar Boutique Hotel

Downtown Cuenca

$312

per person

Nov 13 - Nov 15

found 12 hours ago

Roundtrip flight included

Quito (UIO) to Guayaquil (GYE)

9.6/10 Exceptional! (390 reviews)

Beautiful hotel in a great location. Excellent breakfast included.

Reviewed on Oct 10, 2026

Hotel Río Guayas by Art Hotels Ecuador

Las Peñas

Save 100% on your flight

$2,012

per person

Dec 22 - Dec 29

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Guayaquil (GYE)

10/10 Exceptional! (5 reviews)

Oro Verde Manta

Save 100% on your flight

$670

per person

Dec 31 - Jan 3

found 1 day ago

Roundtrip flight included

Quito (UIO) to Guayaquil (GYE)

9.2/10 Wonderful! (789 reviews)

Hotel Boutique Santa Lucia

Downtown Cuenca

$827

per person

Dec 3 - Dec 7

found 17 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)

9.2/10 Wonderful! (409 reviews)

Hotel Cruz del Vado by Art Hotels Ecuador

$973

per person

Dec 3 - Dec 7

found 17 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)

9.4/10 Exceptional! (45 reviews)

Everything was great. Unfortunately I didn’t check but most of the rooms are windowless. As I’m claustrophobic this was issue. The other thing if you are coming by car is the parking which is about half a block away. These are common themes for hotels in the historic center though. If you are looking for traditional American comfort try hotels on the other side of town

Reviewed on Oct 11, 2026

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco

A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A statue of a soldier on a pedestal with a building in the background.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Numa Pompilio Llona Street while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

1 out of top 10 points of interest in this area

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

1 out of top 10 points of interest in this area

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

San Francisco Hotel Deals

Hilton Colon Guayaquil

Av Francisco de Orellana Mz 111 Guayaquil

Fully refundableReserve now, pay when you stay

$98 nightly

$110 total

Nov 1 - Nov 2

8.8/10 Excellent! (1,001 reviews)

"Most places would offer refills if you bought a cup of coffee at close to 5 USD, however this place, they give you like a 6 oz cup and no refills.. A bit overpriced."

Reviewed on Oct 10, 2026

Wyndham Guayaquil Puerto Santa Ana

Calle Numa Pompilio Llona S N Guayaquil Guayas

Fully refundableReserve now, pay when you stay

$100 nightly

$112 total

Oct 30 - Oct 31

9.4/10 Exceptional! (1,003 reviews)

"El servicio del personal Es muy limitado"

Reviewed on Oct 13, 2026

Oro Verde Guayaquil

9 De Octubre Y Garcia Moreno Guayaquil Guayas

Fully refundableReserve now, pay when you stay

$95 nightly

$107 total

Nov 6 - Nov 7

See all 444 properties in San Francisco

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.